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combined exposure to multiple chemicals

Combined exposure to multiple chemicals: assessing risks across regulatory silos

People are continuously exposed to multiple chemicals from a variety of sources, also referred to as unintentional mixtures. The EU’s Chemicals Strategy for Sustainability towards a toxic-free environment set the objective to better account for mixture effects when assessing risks from chemicals. Available methodologies mainly cover the assessment of predefined groups of chemicals (e.g. dioxins) or assessments within specific regulatory domains (e.g. pesticides). However, they often do not account for all the chemicals to which humans may be potentially exposed, and therefore do not address combined exposure across different regulatory domains. We intend to discuss the current challenges associated with the risk assessment of combined exposure to multiple chemicals and explore how to further advance and harmonise mixture risk assessment across regulatory domains. The outcome of the session is expected to facilitate the identification of possible synergies among national, European and global stakeholders, and stimulate the establishment of legal requirements for chemical mixture risk assessment beyond the current regulatory silos.

Session Coordinator

Session coordinator
Bruno Dujardin (EFSA)

Session Contributors

Session contributors
Stephanie Bopp (JRC)
José Cortinas Abrahantes (EFSA)
Jean-Lou Dorne (EFSA)
George Fotakis (ECHA)
Sara Levorato (EFSA)
Alberto Pistocchi (JRC)
Luisa Ramos Bordajani (EFSA)
Fleur van Broekhuizen (ECHA)

CONFIRMED PROGRAMME AFFILIATES

CHAIRPERSONS
Abstract Session Chairpersons
  • Susanne Hougaard Bennekou, Technical University of Denmark
     
SPEAKERS
Abstract Session Speakers
  • Chris Gennings, Mount Sinai - Novel strategies to assess risks associated with human relevant mixtures
  • Peter Korytar, Directorate-General for the Environment (European Commission) - EU Chemical Strategy for Sustainability and the requirements to account for simultaneous exposure to chemicals across regulatory domains
  • Almut Bitterhof, Directorate-General for Health and Food Safety (European Commission) - Regulatory risk assessment of chemical in food and the need for targeted methodologies in specific policy areas
  • Paul Price, University of Iowa - Possibilities for assessing multiple chemicals across regulatory domains through tiered approaches
  • Christina Rudén, Stockholm University - The mixture assessment factor and the underlying principles
  • Philip Marx-Stoelting, German Federal Institute for Risk Assessment - Risk assessment of combined exposure to multiple chemicals: case studies in food safety
MODERATORS
Abstract Session Moderators
  • Dick Sijm, Netherlands Food and Consumer Product Safety Authority
PANELLISTS
Abstract Session Panellists
  • Almut Bitterhof, Directorate-General for Health and Food Safety (European Commission)
  • Philip Marx-Stoelting, German Federal Institute for Risk Assessment
  • Peter Korytar, Directorate-General for the Environment (European Commission)
  • Christina Rudén, Stockholm University
RAPPORTEURS
Abstract Session Rapporteurs
  • Bruno Dujardin, European Food Safety Authority (EFSA)  
  • Luisa Ramos Bordajandi, European Food Safety Authority (EFSA)
  • Jacob van Klaveren, National Institute for Public Health and the Environment