MANY WAYS

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gut-soil microbiome

Microbiomes, chemicals and health: unravelling an intricate triad

The communities of microorganisms in a defined environment are collectively referred to as microbiomes, and they include Bacteria, Archaea, Eukarya and viruses. Microbiome structures and dynamics across the food system can have both direct and indirect effects on human, animal and soil health, thus occupying a central position in the One Health framework. The gut microbiome is currently viewed as an additional mediator of both potentially beneficial and adverse effects of dietary or environmental exposure to chemicals. Regarding soil microbiome, recent research directly attributes improved plant health and soil fertility to an optimal balance within soil microorganisms. It also appears that this balance may be impaired by several anthropogenic factors, such as plant protection products. Among the challenges to be addressed before integrating microbiome considerations into regulatory safety assessments are the following: (1) a lack of internationally agreed guidance to systematically account for possible effects on microbiomes or effects by microbiomes on host health; (2) the need for more knowledge on how the human microbiome modulates the pharmacokinetics and metabolism of chemicals; and (3) the hindering of translating a decrease in microbiome diversity into a functional consequence due to the absence of standards to define a healthy microbiome. This session aims to improve our understanding of the relevance of microbiome structural changes to chemical risk assessments. The main quest in this scientific domain is to enhance the evidence base that demonstrates the causality between a structurally altered microbiome and subsequent change(s) in metabolic pathways leading to adverse effects in the host.

Session Coordinator

Session coordinator
Caroline Merten (EFSA)

Session Contributors

Session contributors
Jaime Aguilera-Entrena (EFSA)
Catherine Bessy (FAO)
Carmen Diaz-Amigo (FAO)
Beatriz Guerra (EFSA)
Marta Hugas (EFSA)
Arwyn Jones (JRC)
Elisa Pettenati (EFSA)
Reinhilde Schoonjans (EFSA)

CONFIRMED PROGRAMME AFFILIATES

CHAIRPERSONS
Abstract Session Chairpersons
  • Yolanda Sanz, Spanish National Research Council
SPEAKERS
Abstract Session Speakers
  • Jack Gilbert, University of California San Diego - Food additives and contaminants, human health, and the microbiome
  • Benoit Chassaing, National Institute of Health and Medical Research (INSERM) - Microbiota Interaction at the mucosal surface: the importance of no man's land
  • Martin Iain Bahl, Technical University of Denmark - The need to consider human microbiome in chemical risk assessment
  • Sangeeta Khare, US Food and Drug Administration - Unlocking the potential of host-microbiome interaction in the risk assessment
  • Maëva Labouyrie, University of Zurich, Agroscope Reckenholz and Joint Research Centre (JRC) - Are soil microbiome communities and functions influenced by anthropogenic factors?
MODERATORS
Abstract Session Moderators
  • Daphne Miller, University of California Berkeley
PANELLISTS
Abstract Session Panellists
  • Martin Iain Bahl, Technical University of Denmark
  • Benoit Chassaing, National Institute of Health and Medical Research (INSERM)
  • Jack Gilbert, University of California San Diego
  • Sangeeta Khare, US Food and Drug Administration
  • Maëva Labouyrie, University of Zurich, Agroscope Reckenholz and Joint Research Centre (JRC)
RAPPORTEURS
Abstract Session Rapporteurs
  • Catherine Bessy, Food and Agriculture Organization of the United Nations (FAO)
  • Caroline Merten, European Food Safety Authority (EFSA)
  • Javier Moreno, Instituto de Investigación en Ciencias de la Alimentación (CIAL)
  • Elisa Pettenati, European Food Safety Authority (EFSA)