European food is recognised as being safe and of high quality, but it should now also aim for the highest standards of nutrition and sustainability. Food systems at global and EU level need urgent and significant transformation if they are to meet sustainability targets. With the Farm to Fork Strategy, which is at the core of the European Green Deal, there is accelerating momentum in efforts to make our EU food system more resilient and sustainable. Although the European Green Deal puts sustainability at the heart of EU policy-making, and reflects the need for systemic change in food systems, we are still in the process of turning such ambitions into policies and actions. Moreover, steering food systems towards a sustainability transformation remains an immense challenge. Yet, food systems offer many entry points for change. Building on points emerging from the thematic (break-out) sessions over the previous days of the Conference, this plenary session will explore how food safety assessments need to be advanced to keep our food safe, while contributing to making it more nutritious and sustainable. To this end, we will address how a One Health approach could help to deliver more integrated, cross-sectoral and collaborative health assessments, and how such assessments could better inform policies that shape food system transformations.